منابع مشابه
Risk-Informed Safety Margin Characterization
The concept of safety margins has served as a fundamental principle in the design and operation of commercial nuclear power plants (NPPs). Defined as the minimum distance between a system’s “loading” and its “capacity”, plant design and operation is predicated on ensuring an adequate safety margin for safety-significant parameters (e.g., fuel cladding temperature, containment pressure, etc.) is...
متن کاملDetermination of Safety Margin for Hepatotoxic Effect of Mentha Longifolia Essential Oil in Rat
Background: Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. Methods: Adult Wistar rats fed d...
متن کاملRisk-Informed Safety Margin Characterization (RISMC): Integrated Treatment of Aleatory and Epistemic Uncertainty in Safety Analysis
The concept of “margin” has a long history in nuclear licensing and in the codification of good engineering practices. However, some traditional applications of “margin” have been carried out for surrogate scenarios (such as design basis scenarios), without regard to the actual frequencies of those scenarios, and have been carried out in a systematically conservative fashion. In the RISMC proje...
متن کاملScience and serendipity.
Good science demands independent replication of new ideas and results and abandonment of accepted theories in light of more reliable evidence. Failure to comply leads to damaging bad science, as with the falsely claimed association between measles, mumps and rubella vaccination and autism. Progress of good science also often requires serendipity, 'making discoveries by accident and sagacity of ...
متن کاملSerendipity and purpose.
As a medical oncologist-researcher, I am often asked ‘How (or why) did you go into cancer?’ and ‘Isn’t it a depressing field?’ The answer to the second question is a resounding ‘no’, and this brief profile charts my path to answer the first question. Born and raised in Denver, Colorado, I am the daughter of two geologists, so ours was a scientific family. From an early age, my brother, sister a...
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ژورنال
عنوان ژورنال: Perfusion
سال: 2018
ISSN: 0267-6591,1477-111X
DOI: 10.1177/0267659118762710